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PD Clinical Trials - Neuroprogressive & Dementia Network

The best way to be considered for current or future trials is to join the 'Permission to Contact' scheme for the Neuroprogressive & Dementia Network.  This will allow the research team to access your medical records and check whether you are eligible for studies.  To find out more details please visit https://www.nhsresearchscotland.org.uk/research-areas/dementia-and-neurodegenerative-disease. 

To sign up for the 'Permission to Contact' scheme, please complete the online form https://www.nhsresearchscotland.org.uk/research-areas/dementia-and-neurodegenerative-disease/patient-signup-form. Alternatively you can email tay.ndntayside@nhs.scot or call 01382 423086 to have a paper form sent out.

Below are current clinical trials and their inclusion criteria. These will be taking place at the Queen Elizabeth University Hospital, Glasgow.

PD Frontline:

Remote assessment of Parkinsonism supporting ongoing

development of interventions in Gaucher disease

It is an observational study

Inclusion Criteria:

  • Anyone with a diagnosis of Parkinson’s Disease

COBALT:

COmBining memantine And cholinesterase inhibitors in Lewy body dementia Treatment Trial.

This trial will look at the use of Memantine for the treatment of DWLB and PDD symptoms

Inclusion Criteria:

  • Must have Dementia with Lewy Bodies or Parkinson Disease Dementia

  • Must be currently taking chlorinesterase inhibitor

NORAPS:

Noradrenaline for Progressive Supranuclear Palsy Syndromes (PSP)

This trial will look at whether Atomoxetine is safe and well tolerated in patients with PSP and if it will reduce apathy and impulsivity

Inclusion Criteria:

  • Diagnosis of possible or probable PSP

  • Aged between 50-85 years old

  • Stable psycho-active medications for at least 28 days and no plans to change medication

TOPHAT:

Trial of Ondansetron as a Parkinson’s Hallucinations Treatment: The TOP HAT Trial

This trial will look at whether ondansetron, a drug already used in the NHS as an anti-sickness medication, will be an effective and safe treatment for visual hallucinations in people with Parkinson’s or those with Lewy Body Dementia

Inclusion Criteria:

  • Must have Parkinson’s disease or Lewy Body Dementia

  • Experiencing visual hallucinations – seeing things that are not there

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